SPAG4

Across TCGA patient cohorts, SPAG4 mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAG4-associated genes across cancer lineages are SMSP1, LINC02619, and HSBP1P2. Each is linked with SPAG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG4-to-partner and partner-to-SPAG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMSP1 grouped by SPAG4-low versus SPAG4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG4→partner) and Y-score (partner→SPAG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SMSP1 →	+0.035	+5.103	.007	.008	3	2
CESC	LINC02619 →	+0.093	+5.812	<.001	.003	3	2
LUSC	HSBP1P2 →	+0.240	+3.224	.004	.005	3	2
UCEC	RPS27AP14 →	+0.170	+4.386	<.001	<.001	3	2
UCEC	MTCO1P29 →	+0.489	+3.119	.006	.004	3	2
UCEC	RPL35AP33 →	+0.254	+2.798	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

SMSP1 by SPAG4 expression — CESC

Explore this box plot interactively →