SPAG4

Across TCGA patient cohorts, SPAG4 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPAG4-associated genes across cancer lineages are Monocytes, NK cells, and CD8+ Tcm. Each is linked with SPAG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG4-to-partner and partner-to-SPAG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monocytes grouped by SPAG4-low versus SPAG4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG4→partner) and Y-score (partner→SPAG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Monocytes →	+0.012	+5.225	<.001	.034	3	1
STAD	NK cells →	+0.009	+5.597	<.001	.040	3	1
UCEC	CD8+ Tcm →	+0.051	+3.198	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Monocytes by SPAG4 expression — SKCM

Explore this box plot interactively →