SPAG4

Across TCGA cell cohorts, SPAG4 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible SPAG4-associated genes across cancer lineages are GJA8, SHCBP1L, and MROH5. Each is linked with SPAG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG4-to-partner and partner-to-SPAG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJA8 grouped by SPAG4-low versus SPAG4-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG4→partner) and Y-score (partner→SPAG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GJA8 →	+0.020	+5.087	<.001	.004	3	1
URINARY_TRACT	SHCBP1L →	+0.056	+5.087	<.001	.004	3	1
URINARY_TRACT	MROH5 →	+0.006	+5.087	<.001	.004	3	1
LARGE_INTESTINE	KLHL14 →	+0.162	+4.040	<.001	<.001	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GJA8 by SPAG4 expression — URINARY_TRACT

Explore this box plot interactively →