SPAG11B

Across TCGA patient cohorts, SPAG11B mutation is significantly associated with the RNA expression of many other genes, with 139 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAG11B-associated genes across cancer lineages are RPS3AP17, SLC20A1P3, and MIR550A1. Each is linked with SPAG11B in more than 2 cancer types. Because this analysis shows association rather than direction, both SPAG11B-to-partner and partner-to-SPAG11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS3AP17 grouped by SPAG11B-low versus SPAG11B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG11B→partner) and Y-score (partner→SPAG11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS3AP17 →	+0.128	+3.677	.002	.006	3	3
COAD	SLC20A1P3 →	+0.125	+6.917	<.001	<.001	3	2
UCEC	MIR550A1 →	+0.628	+3.599	<.001	.007	3	2
UCEC	RNU6-131P →	+0.590	+3.677	<.001	.006	3	2
UCEC	PSMD14P1 →	+0.231	+4.046	<.001	.003	3	2
SKCM	USF1P1 →	+0.103	+3.356	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 139 associations by consensus.

RPS3AP17 by SPAG11B expression — UCEC

Explore this box plot interactively →