SPAG11A

Across TCGA pan-cancer cohorts, SPAG11A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPAG11A data layer compared with 16 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SPAG11A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPAG11A expression acts as an unfavorable survival marker.

KIRP, HNSC, and BRCA are the cancer types where SPAG11A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.270	0.904	<.001	12	view →
HNSC	OS	Median	II,III,IV	0.222	0.710	.031	6	view →
BRCA	OS	Median	All	0.191	0.579	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SPAG11A–KIRP (OS)

Open the KIRP breakdown →