SPACA9

Across TCGA patient cohorts, SPACA9 mutation is significantly associated with the RNA expression of many other genes, with 478 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPACA9-associated genes across cancer lineages are CLUHP6, CCDC137P, and RNU6-1067P. Each is linked with SPACA9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPACA9-to-partner and partner-to-SPACA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLUHP6 grouped by SPACA9-low versus SPACA9-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA9→partner) and Y-score (partner→SPACA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CLUHP6 →	+0.395	+3.837	<.001	.009	3	2
COAD	CCDC137P →	+0.269	+4.289	<.001	.003	3	2
UCEC	RNU6-1067P →	+0.295	+2.646	.004	.009	3	2
UCEC	MIR521-2 →	+0.257	+3.069	.002	.009	3	2
UCEC	ANP32BP2 →	+0.157	+2.677	.004	.003	3	2
UCEC	YWHABP1 →	+0.293	+2.847	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 478 associations by consensus.

CLUHP6 by SPACA9 expression — COAD

Explore this box plot interactively →