SPACA9

Across TCGA patient cohorts, SPACA9 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPACA9-associated genes across cancer lineages are CD8+ Tem, Macrophages, and Macrophages M1. Each is linked with SPACA9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPACA9-to-partner and partner-to-SPACA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tem grouped by SPACA9-low versus SPACA9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA9→partner) and Y-score (partner→SPACA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ Tem →	+0.004	+4.744	<.001	.040	3	1
UCEC	Macrophages →	+0.023	+2.072	.001	.024	3	1
UCEC	Macrophages M1 →	+0.028	+2.551	<.001	.015	3	1
UCEC	Macrophages M2 →	+0.016	+2.287	.004	.030	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CD8+ Tem by SPACA9 expression — UCEC

Explore this box plot interactively →