SPACA9

Across TCGA cell cohorts, SPACA9 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPACA9-associated genes across cancer lineages are WFDC12, DEFB4A, and CFHR2. Each is linked with SPACA9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPACA9-to-partner and partner-to-SPACA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC12 grouped by SPACA9-low versus SPACA9-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA9→partner) and Y-score (partner→SPACA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	WFDC12 →	+0.249	+4.874	<.001	.002	3	1
BLOOD_Leukemia	DEFB4A →	+0.123	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

WFDC12 by SPACA9 expression — BLOOD_Leukemia

Explore this box plot interactively →