SPACA6

Across TCGA patient cohorts, SPACA6 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPACA6-associated genes across cancer lineages are Tuberin, VEGFR2, and TIGAR. Each is linked with SPACA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPACA6-to-partner and partner-to-SPACA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by SPACA6-low versus SPACA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA6→partner) and Y-score (partner→SPACA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.362	+2.817	.028	.036	3	1
UCEC	VEGFR2 →	+0.642	+2.820	<.001	.036	3	1
UCEC	TIGAR →	+0.190	+2.833	.042	.035	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Tuberin by SPACA6 expression — UCEC

Explore this box plot interactively →