SPACA6

Across TCGA cell cohorts, SPACA6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,049 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPACA6-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Calcium-independent cell-matrix adhesion, and Protein localization to cytoskeleton. Each is linked with SPACA6 in more than 11 cancer types. Because this analysis shows association rather than direction, both SPACA6-to-partner and partner-to-SPACA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by SPACA6-low versus SPACA6-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA6→partner) and Y-score (partner→SPACA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of calcium ion export across plasma membrane →	+0.096	+1.903	<.001	<.001	3	12
BONE	Calcium-independent cell-matrix adhesion →	+0.197	+1.143	<.001	<.001	3	10
BONE	Protein localization to cytoskeleton →	+0.104	+1.594	<.001	<.001	3	10
OVARY	ATP metabolic process →	+0.094	+1.299	<.001	<.001	3	10
BONE	Regulation of telomere maintenance →	+0.080	+1.496	<.001	<.001	3	10
BLOOD_Leukemia	Positive regulation of L-glutamate import across plasma membrane →	+0.151	+1.289	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,049 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by SPACA6 expression — OESOPHAGUS

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