SPACA4

Across TCGA pan-cancer cohorts, SPACA4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SPACA4 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SPACA4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPACA4 expression acts as an unfavorable survival marker.

COAD, LIHC, and UCEC are the cancer types where SPACA4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.045	0.871	<.001	40	view →
LIHC	OS	Median	All	0.025	0.777	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
HNSC	DFS	Median	II,III,IV	0.208	0.685	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SPACA4–COAD (OS)

Open the COAD breakdown →