SPACA4

Across TCGA patient cohorts, SPACA4 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPACA4-associated genes across cancer lineages are MIR362, RNU6-1220P, and CDH12P1. Each is linked with SPACA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPACA4-to-partner and partner-to-SPACA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR362 grouped by SPACA4-low versus SPACA4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA4→partner) and Y-score (partner→SPACA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR362 →	+0.552	+7.954	<.001	.008	3	1
SKCM	RNU6-1220P →	+0.440	+6.021	<.001	<.001	3	1
SKCM	CDH12P1 →	+0.138	+5.199	<.001	.003	3	1
SKCM	OR1P1 →	+0.039	+4.867	<.001	.005	3	1
UCEC	MIR4497 →	+0.753	+4.358	<.001	.001	3	1
UCEC	MIR3132 →	+1.126	+4.882	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

MIR362 by SPACA4 expression — HNSC

Explore this box plot interactively →