SPACA4

Across TCGA patient cohorts, SPACA4 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SPACA4-associated genes across cancer lineages are CD4+ Tem and CD4+ Tcm. Each is linked with SPACA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPACA4-to-partner and partner-to-SPACA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ Tem grouped by SPACA4-low versus SPACA4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA4→partner) and Y-score (partner→SPACA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CD4+ Tem →	+0.032	+6.623	<.001	.019	3	1
HNSC	CD4+ Tcm →	+0.016	+5.468	<.001	.043	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CD4+ Tem by SPACA4 expression — HNSC

Explore this box plot interactively →