SPACA4

Across TCGA cell cohorts, SPACA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,431 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPACA4-associated GO terms across cancer lineages are Regulation of glutamate uptake involved in transmission of nerve impulse, Negative regulation of Arp2/3 complex-mediated actin nucleation, and Regulation of phospholipid translocation. Each is linked with SPACA4 in more than 8 cancer types. Because this analysis shows association rather than direction, both SPACA4-to-partner and partner-to-SPACA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of glutamate uptake involved in transmission of nerve impulse grouped by SPACA4-low versus SPACA4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA4→partner) and Y-score (partner→SPACA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of glutamate uptake involved in transmission of nerve impulse →	-0.229	-0.476	<.001	.001	3	9
LUNG_SCLC	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.236	+0.576	<.001	.001	3	9
LUNG_NSCLC_LUSC	Regulation of phospholipid translocation →	-0.245	-0.557	<.001	.007	3	8
LUNG_NSCLC_LUSC	Positive regulation of phospholipid translocation →	-0.245	-0.557	<.001	.007	3	8
STOMACH	Regulation of clathrin coat assembly →	+0.177	+0.644	<.001	.002	3	8
PANCREAS	3'-UTR-mediated mRNA destabilization →	+0.080	+0.306	.003	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,431 associations by consensus.

Regulation of glutamate uptake involved in transmission of nerve impulse by SPACA4 expression — BREAST

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