SPAAR

Across TCGA pan-cancer cohorts, SPAAR RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SPAAR’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SPAAR RNA is repressed in tumor relative to normal tissue. In most cancer types SPAAR is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

LUAD, KICH, and COAD are the cancer types where SPAAR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPAAR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−2.493	<.001	11	view →
KICH	Male	All	−2.720	<.001	10	view →
COAD	Female	II,III,IV	−0.634	<.001	10	view →
LUSC	All	III,IV	−2.771	<.001	9	view →
BRCA	All	III,IV	−1.951	<.001	8	view →
LIHC	All	II,III,IV	+0.562	<.001	8	view →
KIRP	Male	All	−1.583	<.001	7	view →
BLCA	All	III,IV	−0.424	.033	3	view →
UCEC	All	All	−0.452	.008	2	view →
KIRC	All	All	+0.447	.005	2	view →
PRAD	All	All	−0.309	<.001	2	view →
THCA	All	All	+0.290	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SPAAR–LUAD

Open the LUAD breakdown →