Across TCGA patient cohorts, SP6 protein abundance is significantly associated with the RNA expression of many other genes, with 3,681 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SP6-associated genes across cancer lineages are HMOX1, ARHGEF26, and PRG4. Each is linked with SP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SP6-to-partner and partner-to-SP6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP6→partner) and Y-score (partner→SP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HMOX1 →	+1.121	+0.913	<.001	<.001	3	2
HNSC	ARHGEF26 →	-1.907	-0.846	.009	.009	2	3
HNSC	PRG4 →	-0.996	-1.195	<.001	.003	3	2
PDAC	PNPLA7 →	-0.714	-0.761	<.001	<.001	3	2
UCEC	MUCL1 →	+4.195	+1.685	<.001	<.001	3	2
HNSC	GPR160 →	-1.871	-1.084	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,681 associations by consensus.

Exploration

SP6 survival (RNA) · tumor vs normal (RNA) · all SP6 data types