Across TCGA patient cohorts, SP6 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SP6-associated genes across cancer lineages are SF2, eEF2, and GATA6. Each is linked with SP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SP6-to-partner and partner-to-SP6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP6→partner) and Y-score (partner→SP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SF2 →	-0.129	-2.308	.018	.036	3	2
UCEC	eEF2 →	+0.389	+3.459	.030	.005	3	1
UCEC	GATA6 →	-0.176	-3.000	.023	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.212	-2.308	.012	.036	3	1
UCEC	PCNA →	+0.258	+3.000	.017	.036	3	1
UCEC	Rab25 →	-0.586	-2.321	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

SP6 survival (RNA) · tumor vs normal (RNA) · all SP6 data types