Across TCGA cell cohorts, SP6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,390 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SP6-associated GO terms across cancer lineages are NMDA selective glutamate receptor signaling pathway, Regulation of cytokine-mediated signaling pathway, and Regulation of ubiquitin-dependent protein catabolic process. Each is linked with SP6 in more than 8 cancer types. Because this analysis shows association rather than direction, both SP6-to-partner and partner-to-SP6 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SP6→partner) and Y-score (partner→SP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NMDA selective glutamate receptor signaling pathway →	+0.262	+1.700	<.001	<.001	3	9
OESOPHAGUS	Regulation of cytokine-mediated signaling pathway →	+0.078	+1.743	.006	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of ubiquitin-dependent protein catabolic process →	+0.055	+1.089	.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of intrinsic apoptotic signaling pathway →	+0.098	+1.556	<.001	<.001	3	8
BREAST	Maintenance of cell polarity →	+0.106	+1.352	.004	.008	3	8
URINARY_TRACT	Cilium movement →	-0.049	-1.429	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,390 associations by consensus.

Exploration

SP6 survival (RNA) · tumor vs normal (RNA) · all SP6 data types