Across TCGA cell cohorts, SP6 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SP6-associated genes across cancer lineages are MMP27, CCL19, and ASCL4. Each is linked with SP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SP6-to-partner and partner-to-SP6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP6→partner) and Y-score (partner→SP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MMP27 →	+0.029	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	CCL19 →	+0.080	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	ASCL4 →	+0.006	+5.228	.005	.005	3	1
LUNG_NSCLC_LUAD	OR10G4 →	+0.016	+5.228	<.001	.005	3	1
LARGE_INTESTINE	RAB28 →	+0.608	+3.067	.003	.009	3	1
LARGE_INTESTINE	PTTG2 →	+0.071	+3.719	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

SP6 survival (RNA) · tumor vs normal (RNA) · all SP6 data types