Across TCGA cell cohorts, SP6 mutation is significantly associated with the mutation status of many other genes, with 4,145 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SP6-associated genes across cancer lineages are PYGB, DAAM2, and DLG2. Each is linked with SP6 in more than 3 cancer types. Because this analysis shows association rather than direction, both SP6-to-partner and partner-to-SP6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP6→partner) and Y-score (partner→SP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PYGB →	+3.357	+4.285	.005	.005	1	4
LARGE_INTESTINE	DAAM2 →	+2.584	+3.182	<.001	<.001	1	4
LARGE_INTESTINE	DLG2 →	+2.222	+2.925	.001	.001	1	4
LARGE_INTESTINE	WDR81 →	+2.807	+3.857	<.001	<.001	1	4
LARGE_INTESTINE	ERC2 →	+2.070	+2.807	.002	.002	1	4
LUNG_NSCLC_LUAD	XPO6 →	+5.772	+5.772	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,145 associations by consensus.

Exploration

SP6 survival (RNA) · tumor vs normal (RNA) · all SP6 data types