Across TCGA pan-cancer cohorts, SP5 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SP5 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SP5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SP5 expression acts as an unfavorable survival marker.

HNSC and COAD are the cancer types where SP5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.156	0.710	.002	33	view →
COAD	OS	Median	All	0.391	0.874	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SP5 tumor-vs-normal RNA expression · all SP5 data types