Across TCGA patient cohorts, SP5 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SP5-associated genes across cancer lineages are ERK2, c-Met_pY1235, and EGFR_pY1068. Each is linked with SP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SP5-to-partner and partner-to-SP5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP5→partner) and Y-score (partner→SP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.259	+2.321	.007	.035	3	2
UCEC	c-Met_pY1235 →	+0.106	+2.179	.004	.034	3	2
UCEC	EGFR_pY1068 →	-0.330	-2.321	.008	.035	3	1
UCEC	A-Raf_pS299 →	-0.168	-3.169	.005	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.133	-2.321	.033	.035	3	1
UCEC	JNK2 →	+0.312	+3.009	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

SP5 survival (RNA) · tumor vs normal (RNA) · all SP5 data types