Across TCGA cell cohorts, SP5 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SP5-associated genes across cancer lineages are WDR87, PPP1R2C, and CST8. Each is linked with SP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SP5-to-partner and partner-to-SP5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP5→partner) and Y-score (partner→SP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WDR87 →	+0.021	+3.453	<.001	.009	3	1
BLOOD_Leukemia	PPP1R2C →	+0.307	+5.539	<.001	.003	3	1
BLOOD_Leukemia	CST8 →	+0.062	+5.969	<.001	.001	3	1
BLOOD_Leukemia	OR5P3 →	+0.125	+5.201	<.001	.006	3	1
BLOOD_Leukemia	FAM9A →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	IZUMO3 →	+0.073	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

SP5 survival (RNA) · tumor vs normal (RNA) · all SP5 data types