SP4

Across TCGA cell cohorts, SP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,082 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SP4-associated GO terms across cancer lineages are Microtubule cytoskeleton organization involved in mitosis, Regulation of centrosome duplication, and Centrosome cycle. Each is linked with SP4 in more than 16 cancer types. Because this analysis shows association rather than direction, both SP4-to-partner and partner-to-SP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule cytoskeleton organization involved in mitosis grouped by SP4-low versus SP4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SP4→partner) and Y-score (partner→SP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Microtubule cytoskeleton organization involved in mitosis →	+0.118	+0.877	<.001	<.001	3	17
SOFT_TISSUE	Regulation of centrosome duplication →	+0.068	+0.650	<.001	<.001	3	17
LUNG_SCLC	Centrosome cycle →	+0.090	+1.046	<.001	<.001	3	16
PANCREAS	Nuclear chromosome segregation →	+0.110	+0.996	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.080	+0.588	<.001	<.001	3	16
KIDNEY	Centrosome duplication →	+0.107	+0.763	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,082 associations by consensus.

Microtubule cytoskeleton organization involved in mitosis by SP4 expression — BREAST

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