Q-omics provides the consensus-scored SP3P profile across patient tissues and cancer cell-line models. SP3P expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, SP3P is differentially expressed in 7, with the highest sampling consensus in KICH. Additionally, SP3P RNA expression shows 7,898 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KIRC, KICH, and TGCT as cancer lineages where SP3P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SP3P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SP3P survival associations across molecular data types. SP3P RNA expression shows survival associations in the most cancer types (19). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SP3P RNA expression–survival associations across cancer types. High SP3P expression shows unfavorable associations in COAD, LIHC and CESC, but favorable associations in KIRC, UCS and HNSC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for SP3P RNA expression.
This table summarizes SP3P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for SP3P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SP3P shows lower tumor expression in KICH and KIRC and higher tumor expression in LUAD, COAD, HNSC and LIHC. The KICH box plot shows higher SP3P RNA expression in normal versus tumor tissue (log2 FC = −0.136, t-test p < 0.001).
This table shows molecular features associated with SP3P in patient tissues and cancer cell lines. In patient samples, SP3P shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
