SP3

Across TCGA pan-cancer cohorts, SP3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SP3 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SP3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SP3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

UCEC, PDAC, and HNSC are the cancer types where SP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.494	1.000	.016	12	view →
PDAC	OS	Quartile	All	0.503	0.710	.031	9	view →
HNSC	OS	Median	All	0.449	1.000	.023	6	view →
LUAD	OS	Median	II,III,IV	0.832	0.458	.043	2	view →
LSCC	OS	Median	All	0.800	1.000	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SP3–UCEC (OS)

Open the UCEC breakdown →