SP3

Across TCGA patient cohorts, SP3 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SP3-associated genes across cancer lineages are ACC1, STAT3_pY705, and Caspase-7-cleavedD198. Each is linked with SP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SP3-to-partner and partner-to-SP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by SP3-low versus SP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP3→partner) and Y-score (partner→SP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.281	+2.013	.020	.016	3	2
UCEC	STAT3_pY705 →	-0.417	-2.201	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.667	+2.201	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.097	-2.780	.004	.003	3	1
UCEC	EGFR_pY1068 →	-0.288	-1.874	<.001	.002	3	1
UCEC	eIF4E →	+0.215	+2.201	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

ACC1 by SP3 expression — UCEC

Explore this box plot interactively →