SP3

Across TCGA cell cohorts, SP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,371 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SP3-associated GO terms across cancer lineages are Positive regulation of organelle assembly, Medulla oblongata development, and Regulation of endoplasmic reticulum tubular network organization. Each is linked with SP3 in more than 15 cancer types. Because this analysis shows association rather than direction, both SP3-to-partner and partner-to-SP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of organelle assembly grouped by SP3-low versus SP3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SP3→partner) and Y-score (partner→SP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of organelle assembly →	+0.063	+1.134	.002	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Medulla oblongata development →	+0.164	+0.998	.001	.006	3	16
LUNG_NSCLC_LUSC	Regulation of endoplasmic reticulum tubular network organization →	+0.165	+0.871	.001	.003	3	16
STOMACH	Establishment of mitotic sister chromatid cohesion →	+0.120	+0.590	.005	.002	2	16
UPPER_AERODIGESTIVE_TRACT	Regulation of G2/M transition of mitotic cell cycle →	+0.079	+0.830	<.001	<.001	3	14
SOFT_TISSUE	Regulation of chromatin organization →	+0.082	+0.861	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,371 associations by consensus.

Positive regulation of organelle assembly by SP3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →