SP3

Across TCGA cell cohorts, SP3 mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SP3-associated genes across cancer lineages are CCDC166, C6orf118, and CCDC70. Each is linked with SP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SP3-to-partner and partner-to-SP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC166 grouped by SP3-low versus SP3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP3→partner) and Y-score (partner→SP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCDC166 →	+0.025	+3.855	.005	.007	3	2
BLOOD_Leukemia	C6orf118 →	+0.071	+4.450	<.001	.001	3	1
BLOOD_Leukemia	CCDC70 →	+0.186	+4.037	<.001	.004	3	1
BLOOD_Leukemia	PAX1 →	+0.042	+4.060	<.001	.003	3	1
BLOOD_Leukemia	BRDT →	+0.174	+4.342	<.001	.002	3	1
BLOOD_Leukemia	BTBD16 →	+0.107	+3.959	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

CCDC166 by SP3 expression — BLOOD_Leukemia

Explore this box plot interactively →