SP2

Across TCGA patient cohorts, SP2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,758 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SP2-associated genes across cancer lineages are MARCHF8, PPM1D, and MAGEH1. Each is linked with SP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SP2-to-partner and partner-to-SP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SP2 versus MARCHF8 in BRCA, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP2→partner) and Y-score (partner→SP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MARCHF8 →	+0.764	+0.279	<.001	<.001	3	4
BRCA	PPM1D →	+0.498	+0.253	.007	.002	3	4
UCEC	MAGEH1 →	+0.880	+0.185	<.001	<.001	3	4
UCEC	AKT3-IT1 →	+0.990	+0.219	<.001	<.001	3	4
HNSC	PRKCQ-AS1 →	+0.718	+0.327	<.001	.002	3	4
HNSC	ADGRF4 →	-1.102	-0.413	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,758 associations by consensus.

SP2 vs MARCHF8 — BRCA

Explore this scatter interactively →