SP2

Across TCGA cell cohorts, SP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,036 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SP2-associated GO terms across cancer lineages are Regulation of protein localization to nucleus, Epigenetic regulation of gene expression, and Transcription initiation-coupled chromatin remodeling. Each is linked with SP2 in more than 16 cancer types. Because this analysis shows association rather than direction, both SP2-to-partner and partner-to-SP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to nucleus grouped by SP2-low versus SP2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SP2→partner) and Y-score (partner→SP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of protein localization to nucleus →	+0.066	+0.920	.009	.001	3	17
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.070	+0.559	<.001	.001	3	17
LUNG_SCLC	Transcription initiation-coupled chromatin remodeling →	+0.089	+0.640	.001	<.001	3	17
BREAST	Positive regulation of mitotic cytokinesis →	+0.197	+0.984	<.001	.001	3	16
BREAST	Positive regulation of TORC2 signaling →	+0.101	+0.825	<.001	<.001	2	16
BONE	Heterochromatin organization →	+0.086	+0.728	.003	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,036 associations by consensus.

Regulation of protein localization to nucleus by SP2 expression — BREAST

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