SP2

Across TCGA cell cohorts, SP2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SP2-associated genes across cancer lineages are DGAT2L6, LY6L, and OR14C36. Each is linked with SP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SP2-to-partner and partner-to-SP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DGAT2L6 grouped by SP2-low versus SP2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP2→partner) and Y-score (partner→SP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DGAT2L6 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	LY6L →	+0.020	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR14C36 →	+0.020	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR10C1 →	+0.066	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.042	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR12D1 →	+0.042	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

DGAT2L6 by SP2 expression — OESOPHAGUS

Explore this box plot interactively →