Across TCGA patient cohorts, SP140L protein abundance is significantly associated with the RNA expression of many other genes, with 10,246 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SP140L-associated genes across cancer lineages are BTK, ARHGAP9, and NCKAP1L. Each is linked with SP140L in more than 6 cancer types. Because this analysis shows association rather than direction, both SP140L-to-partner and partner-to-SP140L results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP140L→partner) and Y-score (partner→SP140L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BTK →	+1.449	+0.676	<.001	<.001	3	6
UCEC	ARHGAP9 →	+1.169	+0.643	<.001	<.001	3	6
UCEC	NCKAP1L →	+1.425	+0.635	<.001	<.001	3	6
UCEC	APOL3 →	+1.591	+0.646	<.001	<.001	3	6
UCEC	DOCK2 →	+1.391	+0.660	.001	<.001	3	6
OV	SP110 →	+0.714	+0.428	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,246 associations by consensus.

Exploration

SP140L survival (RNA) · tumor vs normal (RNA) · all SP140L data types