Across TCGA patient cohorts, SP140L protein abundance is significantly associated with the protein abundance of many other proteins, with 12,608 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SP140L-associated proteins across cancer lineages are PSMB5, SP110_S380, and SP140L_S180. Each is linked with SP140L in more than 7 cancer types. Because this analysis shows association rather than direction, both SP140L-to-partner and partner-to-SP140L results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SP140L→partner) and Y-score (partner→SP140L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PSMB5 →	-0.490	-0.612	<.001	<.001	3	7
UCEC	SP110_S380 →	+0.897	+0.567	<.001	.001	3	7
OV	SP140L_S180 →	+1.335	+0.754	.001	<.001	2	8
BRCA	SAMHD1 →	+0.503	+0.465	<.001	<.001	3	6
UCEC	GBP4 →	+1.042	+0.653	<.001	<.001	3	6
OV	TNFAIP8 →	+0.936	+0.795	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,608 associations by consensus.

Exploration

SP140L survival (RNA) · tumor vs normal (RNA) · all SP140L data types