SP140L

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SP140L mutation is significantly associated with the RNA expression of many other genes, with 3,382 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SP140L-associated genes across cancer lineages are USP9YP2, RNA5SP416, and RNA5SP414. Each is linked with SP140L in more than 2 cancer types. Because this analysis shows association rather than direction, both SP140L-to-partner and partner-to-SP140L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP140L→partner) and Y-score (partner→SP140L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECUSP9YP2 →+0.008+3.856<.001.00533
UCECRNA5SP416 →+0.343+1.688<.001.00233
UCECRNA5SP414 →+0.338+1.518<.001.00632
UCECRNA5SP411 →+0.608+1.393.002.00532
UCECEME1 →+0.586+2.203<.001<.00132
SKCMRMND1 →+0.495+2.497.001.00932
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,382 associations by consensus.

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