Across TCGA patient cohorts, SP140L mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SP140L-associated genes across cancer lineages are eEF2, ERK2, and N-Ras. Each is linked with SP140L in more than 1 cancer types. Because this analysis shows association rather than direction, both SP140L-to-partner and partner-to-SP140L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP140L→partner) and Y-score (partner→SP140L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.247	+1.700	.024	.040	3	2
UCEC	ERK2 →	+0.159	+1.584	.006	.017	3	2
UCEC	N-Ras →	-0.079	-1.050	.030	.048	3	2
UCEC	Caspase-7-cleavedD198 →	+0.412	+2.321	.023	.005	3	2
SKCM	HER2_pY1248 →	-0.174	-3.459	.016	.005	3	2
UCEC	EGFR_pY1068 →	-0.237	-1.700	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Exploration

SP140L survival (RNA) · tumor vs normal (RNA) · all SP140L data types