Across TCGA cell cohorts, SP140L mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SP140L-associated genes across cancer lineages are GZMK, OCM2, and OR2D3. Each is linked with SP140L in more than 1 cancer types. Because this analysis shows association rather than direction, both SP140L-to-partner and partner-to-SP140L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP140L→partner) and Y-score (partner→SP140L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GZMK →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OCM2 →	+0.047	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR2D3 →	+0.022	+2.925	<.001	.007	3	1
LARGE_INTESTINE	HBG1 →	+0.086	+3.376	<.001	.002	3	1
BLOOD_Lymphoma	OR6N1 →	+0.225	+4.867	.006	.009	3	1
OVARY	OR10A5 →	+0.036	+4.029	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

SP140L survival (RNA) · tumor vs normal (RNA) · all SP140L data types