SP140

Across TCGA pan-cancer cohorts, SP140 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated SP140 data layer compared with 27 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher SP140 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SP140 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

OV, BLCA, and ACC are the cancer types where SP140 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	All	0.354	0.692	.007	16	view →
BLCA	DFS	Median	All	0.877	0.605	.021	14	view →
ACC	OS	Median	All	0.151	0.632	.006	12	view →
SKCM	OS	Median	III,IV	0.448	0.868	<.001	9	view →
UCEC	DFS	Median	All	0.974	0.827	.013	8	view →
LGG	OS	Median	All	0.101	0.909	<.001	8	view →
LUAD	OS	Median	III,IV	0.057	0.680	<.001	6	view →
HNSC	OS	Median	All	0.465	0.770	.036	3	view →
SCLC	DFS	Median	All	1.000	0.223	.041	3	view →
LUSC	DFS	Median	All	0.860	0.371	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

SP140–OV (OS)

Open the OV breakdown →