SP140

Across TCGA pan-cancer cohorts, SP140 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SP140 data layer compared with 27 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SP140 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SP140 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

GBM, HNSC, and LUAD are the cancer types where SP140 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.588	0.933	.010	15	view →
HNSC	DFS	Tertile	All	0.771	0.505	.008	12	view →
LUAD	DFS	Tertile	All	0.867	0.657	.018	5	view →
UCEC	DFS	Median	II,III,IV	0.369	1.000	.040	4	view →
LSCC	DFS	Tertile	II,III,IV	0.589	0.884	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SP140–GBM (DFS)

Open the GBM breakdown →