SP110

Across TCGA patient cohorts, SP110 mutation is significantly associated with the RNA expression of many other genes, with 4,364 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SP110-associated genes across cancer lineages are CLDND2, YIF1A, and CAPZB. Each is linked with SP110 in more than 2 cancer types. Because this analysis shows association rather than direction, both SP110-to-partner and partner-to-SP110 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDND2 grouped by SP110-low versus SP110-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP110→partner) and Y-score (partner→SP110) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CLDND2 →	+0.505	+2.332	<.001	<.001	3	3
UCEC	YIF1A →	+0.348	+2.009	.001	<.001	3	3
UCEC	CAPZB →	+0.425	+2.664	<.001	<.001	3	3
UCEC	TIMM44 →	+0.434	+1.839	<.001	<.001	3	3
UCEC	NPM3 →	+0.407	+2.408	.003	<.001	3	3
UCEC	FBXL15 →	+0.338	+1.617	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,364 associations by consensus.

CLDND2 by SP110 expression — UCEC

Explore this box plot interactively →