SP110

Across TCGA patient cohorts, SP110 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SP110-associated genes across cancer lineages are ERK2, Gab2, and p27_pT198. Each is linked with SP110 in more than 2 cancer types. Because this analysis shows association rather than direction, both SP110-to-partner and partner-to-SP110 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SP110-low versus SP110-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP110→partner) and Y-score (partner→SP110) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.178	+1.925	.003	.004	3	3
UCEC	Gab2 →	+0.379	+2.058	<.001	<.001	3	2
UCEC	p27_pT198 →	+0.072	+1.678	.036	.021	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.397	-2.459	.005	.018	3	2
UCEC	p70-S6K →	+0.196	+1.697	.001	.012	3	2
UCEC	c-Kit →	-0.167	-1.289	.025	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ERK2 by SP110 expression — UCEC

Explore this box plot interactively →