SP110

Across TCGA cell cohorts, SP110 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,117 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SP110-associated GO terms across cancer lineages are Negative regulation of viral process, Positive regulation of interleukin-4-mediated signaling pathway, and Regulation of interferon-beta production. Each is linked with SP110 in more than 15 cancer types. Because this analysis shows association rather than direction, both SP110-to-partner and partner-to-SP110 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of viral process grouped by SP110-low versus SP110-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SP110→partner) and Y-score (partner→SP110) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of viral process →	+0.156	+1.226	.003	.001	3	16
LUNG_SCLC	Positive regulation of interleukin-4-mediated signaling pathway →	+1.157	+1.915	<.001	<.001	3	15
SOFT_TISSUE	Regulation of interferon-beta production →	+0.079	+1.552	<.001	<.001	3	15
OVARY	Positive regulation of interferon-beta production →	+0.093	+1.157	<.001	.001	3	15
SOFT_TISSUE	Defense response to virus →	+0.084	+1.942	<.001	<.001	3	15
STOMACH	Negative regulation of viral genome replication →	+0.198	+2.068	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,117 associations by consensus.

Negative regulation of viral process by SP110 expression — KIDNEY

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