SP110

Across TCGA cell cohorts, SP110 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SP110-associated genes across cancer lineages are BMP15, MS4A14, and SPINK8. Each is linked with SP110 in more than 1 cancer types. Because this analysis shows association rather than direction, both SP110-to-partner and partner-to-SP110 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMP15 grouped by SP110-low versus SP110-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP110→partner) and Y-score (partner→SP110) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	BMP15 →	+0.030	+4.906	<.001	.006	3	1
OESOPHAGUS	MS4A14 →	+0.053	+4.906	<.001	.006	3	1
OESOPHAGUS	SPINK8 →	+0.263	+4.906	<.001	.006	3	1
OESOPHAGUS	C2orf83 →	+0.020	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR4A47 →	+0.029	+5.228	<.001	.005	3	1
LARGE_INTESTINE	ADRA1A →	+0.125	+3.103	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

BMP15 by SP110 expression — OESOPHAGUS

Explore this box plot interactively →