SP100

Across TCGA cell cohorts, SP100 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,824 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SP100-associated GO terms across cancer lineages are Pattern recognition receptor signaling pathway, Negative regulation of viral genome replication, and Negative regulation of viral process. Each is linked with SP100 in more than 17 cancer types. Because this analysis shows association rather than direction, both SP100-to-partner and partner-to-SP100 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pattern recognition receptor signaling pathway grouped by SP100-low versus SP100-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SP100→partner) and Y-score (partner→SP100) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Pattern recognition receptor signaling pathway →	+0.085	+2.221	<.001	.001	3	18
PANCREAS	Negative regulation of viral genome replication →	+0.202	+1.147	<.001	<.001	3	18
STOMACH	Negative regulation of viral process →	+0.161	+2.253	<.001	.001	3	18
OVARY	Cytoplasmic pattern recognition receptor signaling pathway →	+0.096	+2.208	<.001	<.001	3	17
OESOPHAGUS	Innate immune response-activating signaling pathway →	+0.079	+2.108	<.001	.002	3	17
SOFT_TISSUE	Maintenance of protein location in cell →	+0.145	+2.316	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,824 associations by consensus.

Pattern recognition receptor signaling pathway by SP100 expression — OESOPHAGUS

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