Across TCGA pan-cancer cohorts, SP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SP1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SP1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where SP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	1.000	0.652	.017	9	view →
HNSC	OS	Median	All	0.780	0.910	.006	5	view →
PDAC	DFS	Tertile	All	0.851	0.715	.016	1	view →
LSCC	DFS	Tertile	II,III,IV	0.515	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SP1 tumor-vs-normal RNA expression · all SP1 data types