Across TCGA patient cohorts, SP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,912 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SP1-associated proteins across cancer lineages are SMARCC2, SNRPD3, and CMIP_S377. Each is linked with SP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SP1-to-partner and partner-to-SP1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SP1→partner) and Y-score (partner→SP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SMARCC2 →	+0.314	+0.711	<.001	<.001	3	5
PDAC	SNRPD3 →	+0.364	+0.307	<.001	<.001	3	5
UCEC	CMIP_S377 →	-0.592	-0.382	.008	.005	3	5
LSCC	ZMYND8 →	+0.226	+0.410	<.001	<.001	3	5
BRCA	MYG1 →	+0.292	+0.392	<.001	.001	3	5
COAD	MRPL32 →	-0.447	-0.370	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,912 associations by consensus.

Exploration

SP1 survival (RNA) · tumor vs normal (RNA) · all SP1 data types