Across TCGA patient cohorts, SP1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,060 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SP1-associated genes across cancer lineages are ZNF740, KANSL2, and C2CD5. Each is linked with SP1 in more than 7 cancer types. Because this analysis shows association rather than direction, both SP1-to-partner and partner-to-SP1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP1→partner) and Y-score (partner→SP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF740 →	+0.555	+0.209	.001	.005	3	8
UCEC	KANSL2 →	+0.689	+0.225	.003	.003	3	6
UCEC	C2CD5 →	+0.575	+0.216	.002	.001	3	5
LSCC	XPA →	+0.700	+0.289	<.001	<.001	3	5
HNSC	BRD3 →	+0.493	+0.215	.001	.001	3	5
HNSC	PCBP2 →	+0.627	+0.198	.006	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,060 associations by consensus.

Exploration

SP1 survival (RNA) · tumor vs normal (RNA) · all SP1 data types