Across TCGA patient cohorts, SP1 mutation is significantly associated with the RNA expression of many other genes, with 3,320 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SP1-associated genes across cancer lineages are RNA5SP205, RNA5SP420, and MIR8061. Each is linked with SP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SP1-to-partner and partner-to-SP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP1→partner) and Y-score (partner→SP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP205 →	+0.228	+4.733	<.001	.004	3	3
UCEC	RNA5SP420 →	+0.306	+1.481	.003	.006	3	3
OV	MIR8061 →	+0.633	+6.704	<.001	<.001	3	2
CESC	RPL21P88 →	+0.099	+3.536	<.001	.002	3	2
CESC	RN7SL732P →	+0.159	+4.469	.002	<.001	3	2
BLCA	OR5A2 →	+0.044	+3.870	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,320 associations by consensus.

Exploration

SP1 survival (RNA) · tumor vs normal (RNA) · all SP1 data types