Across TCGA patient cohorts, SP1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SP1-associated genes across cancer lineages are MEK1, PDCD4, and ATM. Each is linked with SP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SP1-to-partner and partner-to-SP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP1→partner) and Y-score (partner→SP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.432	+2.058	<.001	<.001	3	2
UCEC	PDCD4 →	-0.316	-1.523	.035	.008	3	2
UCEC	ATM →	-0.304	-1.986	.035	.029	3	2
UCEC	cIAP →	+0.111	+1.550	.011	.004	3	2
UCEC	14-3-3_beta →	-0.109	-2.475	<.001	.001	3	1
UCEC	EGFR_pY1068 →	-0.231	-1.584	.003	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

SP1 survival (RNA) · tumor vs normal (RNA) · all SP1 data types