Across TCGA cell cohorts, SP1 mutation is significantly associated with the RNA expression of many other genes, with 117 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SP1-associated genes across cancer lineages are GRIFIN, BET1, and NEIL3. Each is linked with SP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SP1-to-partner and partner-to-SP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SP1→partner) and Y-score (partner→SP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GRIFIN →	+0.061	+4.977	<.001	.007	3	1
LARGE_INTESTINE	BET1 →	+0.526	+3.299	.002	.004	3	1
LARGE_INTESTINE	NEIL3 →	+0.684	+3.212	.006	.006	3	1
LARGE_INTESTINE	C12orf57 →	+0.903	+3.212	.002	.006	3	1
LARGE_INTESTINE	RABGGTB →	+0.806	+3.212	<.001	.006	3	1
LARGE_INTESTINE	RPS2 →	+0.489	+3.212	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

Exploration

SP1 survival (RNA) · tumor vs normal (RNA) · all SP1 data types